This research evaluates a climate-land cover-water resources interconnected system in a semi-arid watershed with mini- mal human impact from 1970 - 2009. We found 0.9°C increase in temperature and 10.9% decrease in precipitation. The temperature exhibited a lower increase trend and precipitation showed a similar decrease trend compared to previous studies. The dominant land-cover change trend was grass and forest conversion into bush/shrub and developed land and crop land into barren and grass land. These alterations indicate that changes in temperature and precipitation in the study area may be linked to changes in land cover, although human intervention is recognized as the major land-cover change contributor for the short term. These alterations also suggest that decreasing human activity in the study area leads to developed land and crop land conversion into barren and grass land. Hydrological responses to climate and land-cover changes for surface runoff, ground- water discharge, soil water content and evapotranspiration decreased by 10.2, 10.0, 4.1, and 10.5%, respectively. Hydrological parameters generally follow similar trends to that of precipitation in semi-arid watersheds with minimal human development. Soil water content is sensitive to land-cover change and offset relatively by the changes in precipitation.